Speaking at the League of United Latino American Citizens' annual conference in Washington, Clinton explicitly asked attendees for their help turning out the Latino vote in November.
Clinton spent the first half of her speech discussing policy matters, specifically the immigration and economic planks expected in the Democratic Party platform.
The second half was reserved for politics, and Clinton took dead aim at her likely general election rival.
"What happens this November really matters, my friends," Clinton said, adding, "Now, I think that's true in every election, but this one is different, isn't it?"
From its launch, Trump's campaign has been at odds with many Hispanic groups. Last June, Trump announced his presidential aspirations in a speech that labeled Mexican immigrants as "rapists" who "bring crime."
Clinton listed several other occasions when the Republican fell afoul of Hispanics, at times tying him to other Republicans and at others playing Trump as more extreme than his party.
"Next week in Cleveland they will nominate someone who thinks Latino outreach is tweeting a picture of a taco bowl," Clinton said, referencing Trump’s infamous Cinco de Mayo celebration tweet, which he labeled "I love Hispanics!”
The Republican National Committee slammed “the world-class pandering we have come to expect from Hillary Clinton” in a statement on her remarks.
"Whether it’s her constant shapeshifting on immigration, her rapid backtracking on trade deals she once supported, or her reckless usage of a secret email server to cover up her own conflicts of interest while secretary of state, Hillary Clinton has proven her number one concern is her own political gain,” the RNC said.
Clinton briefly mentioned Jeb Bush, a former rival of Trump's for the Republican nomination whose powerful family has maintained its opposition to the real estate mogul. Trump, Clinton said, "criticized Jeb Bush for speaking, and I quote, 'Mexican.' You cannot make this up."
Clinton finalized her speech with an appeal for Latino leaders to promote voter participation in their communities.
Latinos have historically been reluctant to register and show up on Election Day.
The group has the lowest voter participation rates of any large demographic group in the country, a fact that some attribute to Hispanics' relative youth — younger voters are less likely to participate — and concentration in solid red or blue states such as Texas and California.
Latino voters are expected to be crucial in November in key swing states including Colorado, Florida and Nevada.
